microLIQUID is now a TE Connectivity Company.

Microfluidic Manufacturing technologies

Posted By Borja Barredo / Technology Blog / Lab on a Chip, microfluidic chip, microfluidics / No hay comentarios

Microfluidic Chips Manufacturing Technologies

microLIQUID uses several technologies for the fabrication of microfluidic structures in prototypes and serial production of microfluidic flexible chips.

For Microfluidic structures

Hot Embossing.
Etching (Wet and dry).
Breaking and Dicing.
Bonding (thermal and anodic), we bond any polymer or substrate.
Flexible chips.

For Serial production

Injection molding.

CNC Micromachining.

For Integrated electrodes

  • Metal deposition via sputtering.
  • Metal deposition via vaporization.

For Chip holders:  microfluidic connectors

Injection molding.
CNC Micromachining.

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Microfluidics: What is the correct material?

Posted By Borja Barredo / Technology Blog / Lab on a Chip, microfluidic chip, microfluidics / No hay comentarios

Microfluidics Applications: Materials for different utilization

In microLIQUID we mainly use polymer materials in our product development and also glass and metals. We use them to fabricate microfluidic chips,different architectures,Integrate electrodes on microfluidic structures and Connectors (Microfluidic Chip holders).

Microfluidic structures

  • SU-8:Very precise and a good solution for prototypes.
  • COP or COC: Very good characteristics for health applications.
  • PMMA or Plexiglass clean room microfluidics.
  • PC: polycarbonate.
  • PDMS: Polydimethylsiloxane.
  • Substrates of Glass, silicon or your own processed wafers.

Integrate electrodes on microfluidic structures

  • Gold.
  • Platinum.
  • Titanium.
  • Chromium.
  • Copper.
  • Aluminium.
  • Nickel.

microLIQUID integrates metallic structures on SU8, COP, COC, PDMS, silicon and glass.

Connectors (Chip holders)

  • Plastic.
  • Metal.

The connectors have electrical connexion via Standard PCB(Printed circuit Boards).

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microLIQUID joins Food for Life-Spain Technological Platform

Posted By Borja Barredo / News / Lab on a Chip, microfluidics, microLIQUID / No hay comentarios

MicroLIQUID has reached an agreement to join the technology platform FOOD FOR LIFE – Spain(PTF4LS), working on the development of detection systems in Food & Health, along with Food Security.

Food for Life- Spain logo

Food for Life- Spain

Technology Platforms like this, are a group of stakeholders in a particular sector, led by industry, with the aim of defining a Strategic Research Agenda (acronym: SRA) on important issues and great social relevance, in which achieve European objectives of growth, competitiveness and sustainability depend on technological advances and research in the medium and long term.

Technology Platforms are based on the definition of a Strategic Research Agenda and mobilizing the critical mass of research and innovation effort needed.
Guide research in supply to industrial interests and the interests of society. The aim of this platform is to reach a consensus among all (companies and researchers) on issues of interest to be investigated. This consensus will materialize in the development of a Strategic Research Agenda.

The intention is that projects to be submitted to the various national R & D + Innovation plans are made based on the needs of the sector and not just those of the research centers or other stakeholders only.

microLIQUID joins in the project based on the capacity of the company of generating new detection systems in the Food & Health sector, like the example we see in the picture

point of care and detection systems based in microfluidics

microLIQUID develops and manufactures  new detection systems based in microfluidics in the Food & Health sector





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Distribution Agreement fProbes microLIQUID – Cibertec in Spain

Posted By Borja Barredo / News / cibertec, Earth Sciences event, epilepsy, Ikerlan, microfluidics, microLIQUID, Neurology, neuron, Neuronal, Neurophysiology, Neuroscience / No hay comentarios

microLIQUID signs a distribution agreement with Cibertec , Key distributor of neuronal microprobes fProbes in Spain.

microfulidic microprobes fProbes

microfluidic microprobes fProbes

On February 26 was made official the agreement that the two companies have signed for the distribution of the neuronal microprobes Fprobes for research in EPILEPSY, PARKINSON and other BRAIN DISEASES. Cibertec will be the exclusive dealer entitled to sell the product in the Spanish national market.

Cibertec is the Spanish leader in production and distributor of devices and equipment for research and teaching in neurology and in several other fields. The company was constituted in 1977 and was born as a manufacturer of a limited number of equipment, range of stimulators and electrophysiology window discriminator, but with an advanced design.

Over the years Cibertec have been manufacturing a wide range of new equipment, mostly under specifications of its customers, and at the same time marketing products manufactured by prestigious companies.

The new distribution agreement allows Cibertec to sell the fProbes and the fPack, and also the developments coming soon in the Neuro field by microLIQUID.

The fProbes are probes with integrated electrophysiological recording and the simultaneous release of drugs in the brain with ,currently, experimental purposes. For proper functionality, fProbes are integrated in a package, the fPack, which ensures the electrical and fluidic connection.
This technology has been developed as a result of scientific collaboration between the Cajal Institute CSIC, the IKERLAN Technology Centre and the
University of Zaragoza

Here you can find the link where all is explain in deep:


Both companies have started to work the Beta Tester Program for a better landing in the market. This beta program is simply the starting point, offering to researchers a pack of one encapsulate and 5 units of the probes, in order to test the product.

Microliquid has found a perfect strategic partner to output its own product and at the same time Cibertec complete its product portfolio with a unique product in the market.
The advantages of this agreement are clear and the complementary fields of both companies allow developing the market together.

CIBERTEC Neuroscience

CIBERTEC Neuroscience – www.cibertec.es

microLIQUID expert in microfluidics

microLIQUID expert in microfluidics – www.microliquid.com

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Microfluidic Probes: EPILEPSY Research in HUMAN awarded by FIPSE

Posted By Borja Barredo / News / epilepsy, idival, Lab on a Chip, microfluidics, neuron, Neuroscience, parkinson / No hay comentarios

Microfluidic Probes for EPILEPSY Research

Microfluidic microprobes to record neuronal activity and local application of drugs, to be applied to the electrophysiological monitoring or pre-surgical intra-operative of adult patients with refractory epilepsy, awarded with the FIPSE Project in Phase 1.

fprobes - microfluidic microprobes for epilepsy research

fprobes – microfluidic microprobes for epilepsy research

This project, coordinated by the Department of Neurophysiology at the Hospital Marqués de Valdecilla-Valdecilla Health Research Institute (IDIVAL) (Dr. José Luis Fernández Torre), integrates researchers from the CSIC Cajal Institute in Madrid (Dr. Liset Menendez de la Prida ) and the  microLIQUID in Basque Country (Dr. Ane Altuna), a multidisciplinary team with a long research career in their respective fields of expertise.

Dr. José Luis Fernández Torre is the principal investigator of this project, is Head of Clinical Neurophysiology, University Hospital Marqués de Valdecilla, Vice president of the National Committee for Clinical Neurophysiology, Associate Professor in the Department of Physiology and Pharmacology, Faculty of Medicine Santander (UNICAN) and creator and in charge  of the Research group  for clinical research associate of Neurophysiology in Epilepsy and Neurointensives in the Valdecilla Research Institute (IDIVAL). He has published over 80 articles in prestigious journals such as Clinical Neurophysiology, Epilepsy, Neurology and Journal Neurology, Neurosurgery and Psyschiatry.

Liset Menendez de la Prida is doctor in Neuroscience (1998) in the program of the prestigious Institute of Neurosciences of Alicante, is an international expert in the study of the neural mechanisms of high frequency oscillations (or HFOs) in epilepsy. She has participated in numerous international projects of the European Commission and prestigious institutions such as the Human Frontier Science Program, and published in the top journals in the field as Neuron and Nature Neuroscience. It has 5 accredited six-year research periods for her scientific activity, she has directed four doctoral theses and has 2 ongoing, and regularly participates as a speaker at the prestigious Gordon Conference on Epilepsy and guest in prestigious foreign institutions.

Ane Altuna is doctor by the University of the Basque Country (2012), currently head of R & D in Microliquid, she developed her career in science and technology in IKERLAN where she designed and finalized the production of integrated electrical probes for brain recording. Expert in SU-8, biocompatible polymer that makes up the structural material of our integrated probes, has published her work in the most prestigious journals in the field, such as Lab-on-chip or Biosensors and Bioelectronics.

microfluidic microprobes for Epilepsy Research

microfluidic microprobes – Epilepsy

The aim of the project is to assess the feasibility of integrated microscopic probes (<150 microns diameter) aimed to record neuronal activity and to deliver drugs locally for preoperative or intraoperative electrophysiological monitoring of adult patients with refractory epilepsy evaluated for surgery or and neurocritical patients (in coma) with spontaneous intracerebral hemorrhage, subarachnoid hemorrhage, malignant stroke and severe head trauma during continuous multimodal monitoring. With this project they intend to evaluate: a) the clinical opportunity for intracranial integrated recordings and local drug delivery solutions; b) the technical adjustments required to bring current experimental prototypes to pre-clinical tests; c) the activities of both basic and clinical research necessary to bring our technology to the field of clinical intracranial monitoring.

Most of the probes used in the clinic for recording EEG and ECoG are the macroelectrodes type, with dimensions ranging from a few tens of microns (> 500 microns) to a few millimeters (1-2 mm). The use of such electrodes has played a key role in the development of new functional therapies used successfully in the treatment of various neurological diseases such as Parkinson‘s disease, Epilepsy or chronic intractable pain.

microfluidic microprobes detail for Epilepsy Research

microfluidic microprobes detail for Epilepsy Research

The project proposes the design of cutting-edge biomedical technologies focused on the development of fProbes, integrated probes for neural recording and delivery of drugs in local, currently marketed by microLIQUID in the field of basic neuroscience. It is planned to evaluate the clinical and technical aspects associated with its implementation as a solution to the problem of intracranial clinical monitoring of refractory epilepsy and intracerebral hemorrhage, stroke and traumatic brain injury.

fProbes is the trademark under which microLIQUID is currently marketing our integrated fluidic solutions for neural recording and drug delivery in local in the field of neuroscience

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Posted By Borja Barredo / Blog With Right Sidebar, News / 2016, Branding Components, Earth Sciences event, Flowing matter, HTML, january, Laura Campo Deaño, Life, microfluidics, microLIQUID, Newtonian fluid, Nuno Araújo, Platform, Porto, Porto University, Portugal, Video, Web Design, WordPress / No hay comentarios

Microfluidic Event in Portugal

MicroLIQUID has been present and participating in the FLOWING MATTER 2016

Our company moves to Porto to be present at the conference acting as one of the sponsors of the Event.

microfluidic Flow sensor

microfluidic Flow sensor

microfluidic conference FLOWING MATTER 2016

microfluidic conference FLOWING MATTER 2016

In the next link we can see all the companies invited as sponsors:


Flowing matter lies at the crossroads between industrial processes, fundamental physics, engineering and Earth Sciences. Depending on the microscopic interactions, an assembly of molecules or of mesoscopic particles can flow like a simple Newtonian fluid, deform elastically like a solid or behave in a complex manner. When the internal constituents are active, as for biological entities, one generally observes complex large-scale collective motions.

A fundamental understanding of flowing matter is still missing impeding scientific progress, effective control on industrial processes, as well as accurate predictions of natural phenomena. Flowing matter frequently presents a tight coupling between small-scale structures and large-scale flow urging for a unifying approach. The Action will coordinate existing research efforts into a synergetic plan of collaborations and exchanges to develop an innovative multi-scale approach able to encompass the traditional micro-, meso-, and macro-scales descriptions.

Breakthroughs in the understanding of flowing matter will impact on fundamental key scientific issues, such as the glass, the elasto-plastic and the jamming transitions, as well as industrial applications including health, energy, cosmetics, detergents, food, paints, inks, oil and gas. The conference has covered the three main topics of the COST Action: complex fluids, active matter and complex flows.

The Local Organizers of the conference (Laura Campo Deaño and Nuno Araújo are Microliquid partners, Porto University people, and we are proud and happy for this mutual collaboration.

The event has been a total success and sure that in a near future in many other things or in next editions we will collaborate again. Great work from the Porto Team!!!

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Proyecto Financiado por MINECO: Microfluidic Chip Biosensor based in DNA – INNPACTO Subprogram

Posted By Borja Barredo / News / Biosensor, DNA, microfluidics, microLIQUID / No hay comentarios

Microfluidic Chip: Biosensor based on DNA

microLIQUID has participated in a public funded project by the MINISTERIO de ECONOMÍA Y COMPETITIVIDAD through the INNPACTO Subprogram (Reference Number: IPT-2011-1290-010000)


Desarrollo de un BIOSENSOR Universal basado en ADN para Diagnóstico rápido de patógenos: aplicación específica asociada a producción en ganado bovino

El objetivo principal de este proyecto financiado con fondos públicos es el diseño, desarrollo y validación de un novedoso dispositivo universal abierto, compacto, de fácil manejo basado en la tecnología Microarray LDR con una fase pre-analítica que permita trabajar sobre diferentes matrices y que posibilite una rápida detección e identificación inequívoca simultánea de patógenos responsables de patologías infecciosas asociadas a producción en ganado bovino, incluyendo el estudio de bacterias, algas, mohos y virus.

microfluidic biosensor of DNA

Microfluidic Chip: biosensor of DNA

Como Objetivos específicos:

Validación del prototipo, Pre diseño Industrial del microarray  y diseño del sistema Lab on a Chip, para su posible comercialización, fase previa para el establecimiento de un sistema de prestación de servicios clínicos con el microarray.

Se complementa con una aplicación específica para detección precoz en etapa subclínica de patógenos, de difícil erradicación asociados a la producción en bovinos, válido para diferentes matrices (leche, ubre o muestras ambientales)basada en la tecnología de microarray (dispositivo Lab on a Chip)

Implantación y nuevos desarrollos de las últimas tecnologías y sistemáticas de diagnóstico rápidas basadas en métodos moleculares rápidos automatizables con alta densidad de integración de dianas (análisis simultáneo de cientos de resultados) con menos exigencia de recursos, de coste ajustado, amistosas y que no requieren personal tan cualificado, este caso para el diagnostico precoz de MAMITIS, especialmente en ausencia de sintomatología(etapa subclínica), específicamente aplicada a la realidad de las granjas.

Que el tiempo de diagnóstico sea inferior a 24 horas, para tomar acciones mejores y más rápidas en el control preventivo de esta enfermedad, especialmente en casos asintomáticos como en la mamitis subclínica.

Desarrollar una herramienta válida para el control preventivo de mamitis y por tanto para control de riesgo en granja.

Microfluidics laboratory

La propuesta tecnológica diseñada se basa en un biochip de ADN de cámara múltiple asociado a una plataforma de microarray y a una PCR integradas donde:
– El biosensor integra todas las etapas del proceso (extracción, amplificación y detección) en un único dispositivo con una seguridad diagnóstica muy superior a los métodos tradicionales, permitiendo incluso portabilidad.
– Se utiliza la novedosa tecnología de la reacción de detección de la ligasa (LDR), más eficiente, especifica y rápida con un microarray universal que permite un diseño configurable según el grupo/s que interese identificar permitiendo escoger perfiles específicos de biotipos de zonas características y añadir o modificar especies en el mismo chip con el consecuente ahorro en costes.
– La combinación de sondas en la reacción de ligación y de un microarray universal crea un sistema integral, compacto, completamente abierto que en cada momento se puede adaptar a las necesidades del usuario, empleando más o menos sondas o intercambiándolas a conveniencia. No hay soluciones tecnológicas comercializadas equiparables en el mercado.
La primera aplicación diseñada pertenece al sector agroalimentario y salud animal. Su selección de debe al elevado número de diferentes especies y grupos diana involucrados que comparte con numerosas patologías (incluyendo salud humana) Grupos de especies incluidos en el biosensor), experiencia del grupo investigador, así como orientación al mercado dada su relación directa con la productividad entre otros aspectos


REIA Análisis Especiales S.A. , Universidades de Santiago de Compostela ,  microLIQUID S.L. Feiraco S. Coop Gallega, Vacunek S.L. e IK4-Ikerlan 


2011- 2013


MINECO – Subprograma INNPACTO  (Nº Exp: IPT-2011-1290-010000)



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